Latanoprost is the most widely used prostaglandin for the treatment of elevated IOP in glaucoma. Latanoprost is manufactured at Cayman Chemical in Ann Arbor, MI and at Cayman Pharma, our Czech subsidiary. GMP material from both Cayman Chemical and Cayman Pharma, which conforms to the USP, EP, and IP Monographs, is available. Each site maintains a unique DMF; they have been filed with the US FDA, Canada, India, several EU member states, and several other countries.